AP® Biology—Semester A

Crystal clear cellular service.

  • Course Length: 18 weeks
  • Course Type: AP
  • Category:
    • Science
    • College Prep
    • High School

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This course has been approved by the College Board, which indicates that the syllabus "has demonstrated that it meets or exceeds the curricular expectations colleges and universities have for your subject." Please contact sales@shmoop.com if you would like to add this course to your official record of AP course offerings.


Dr. Ian Malcolm once said that "life, uh, finds a way," but he didn't really go into the details. This Advanced Biology course is for those people who want to know more about just how life goes about its business.

We'll cover it all—whether you're interested in the pint-sized work done inside our cells, the DNA instructions that code for every protein we make, the grand detective story that is the history of life on Earth, or even if you just think plants and animals are cool and want to know more about them.

This course has something for everybody. Here's a taste of what you'll find:

  • In-depth interviews with the Fab Four of biology: carbs, fats, proteins, and nucleic acids
  • The pros of prokaryotes and the eus of eukaryotes (and how to tell them apart)
  • How plasma membranes help cells keep their insides in, their outsides out, and then shuffle stuff between those categories as needed
  • The cellular alternatives to Wi-Fi and notes passed in class (you'd think cells would use cell phones to communicate with each other, though)
  • Where all the free energy used by life on Earth comes from, and some of the clever ways that have been developed to use it up
  • How organisms grow big and strong by mitosis or put the usual cell cycle on spin cycle to pass their traits to the next generation using meiosis
  • Go beyond making puns about biology and make Punnett squares for how traits are inherited
  • A kitchen sink full of molecular genetics: DNA, RNA, proteins, transcription factors, horizontal gene transfer, and some of the ways scientists have taken advantage of all these things to do some mondo cool stuff
  • A guided tour of the man, the myth, the legend, Charles Darwin—and more importantly, the evidence for his theory of how life evolved

We've got in-depth, Shmoopy readings that lay out all the juicy details. We've got all kinds of activities to (figuratively) stretch your brain—including inquiry-based hands-on and virtual labs. We've got gobs of practice problems to hone your skills. In short, we've got it all.

Ready to spend your days dreaming about Punnett squares? Waxing poetic about evolution? Then come on, find a way to take this course.

P.S. Advanced Biology is a two-semester course. This is Semester A, and Semester B will be coming soon.

Technology Requirements

Let's see, you'll need a computer with an internet connection to use this online course. Seems legit. A tablet works, too, if you don't mind typing on it. You'll also want a calculator—it can be a four-function (plus square root) calculator, a scientific calculator, or a graphing calculator.

Required Skills

This course offers the high school equivalent of a college-level biology course. The university eggheads assume you've already taken a general high school biology course, so we're going to do the same.


Unit Breakdown

1 AP® Biology—Semester A - The Building Blocks of Biology

Life looks really complex at first glance (and second glance, and after a lifetime of study), but it's built upon a fairly basic foundation. In this opening unit, we'll take a look at the basic building blocks of biology: the four macromolecules. Knowing the properties of carbohydrates, nucleic acids, proteins, and lipids gives us a leg up on understanding everything that's made out of them—which is pretty much everything in biology. We'll also want to know a thing or two about water and how it can carry other molecules around without requiring any extra energy. We're lazy, and our cells are, too, so we get a lot of mileage out of this.

2 AP® Biology—Semester A - A Cellular Way of Life

With the basics out of the way, we can start applying them to cells, the simplest form of life. We'll look at two different types of cells: those who messily dump all their components into the cytoplasm and those who package their innards into organelles. After that, we'll take a good look at the plasma membranes of cells. These things are made out of a double layer of phospholipids (which, hey, is a type of macromolecule), and they control what gets into or goes out of a cell or organelle. Plasma membranes of cells are part bouncer, part logistics manager. Then we'll see how cells communicate with each other over short, medium, and long distances.  The unit wraps up with the typical life cycle of a cell and how cells create more cells through mitosis. What a life.

3 AP® Biology—Semester A - Metabolism and Homeostasis

We've all been there—it's not even 10:30 a.m. and your tummy is rumbling because you're hungry like whoa. Even our cells have been there because they've got to eat, too. To be honest, we're hungry because they're hungry. That's because our cells need to take in and break down materials from our food to get the molecules and energy they need to maintain themselves. In this unit, we'll cover the hows and whys of metabolism. That includes the source of energy for all life on Earth, photosynthesis of the sun's energy by plants. The rest of us just mooch off of them, breaking down the sugars they make using cellular respiration.

4 AP® Biology—Semester A - Mendelian Genetics

If you've got your mother's eyes, your father's nose, or your great-grandpa's legendary tongue-twisting ability, you can thank your genes. A lot of the traits we have are inherited from our parents, according to a set of rules first discovered by a bored monk named Gregor Mendel. In this unit, we'll learn the laws for how traits are passed from one generation to the next, how those laws can be broken, and the genetic disorders that can happen when the genes themselves break. Along the way, we'll tackle meiosis and add Punnett squares, chi-square tests, and gene linkage maps to our biology toolkits.

5 AP® Biology—Semester A - Molecular Genetics

Now that we've learned about how inheritance works when talking about traits, let's dive into the nitty-gritty. In this unit, we’ll talk about how genetic information really gets transferred—at the molecular level—and makes us into who we are today. DNA, RNA, transcription, translation, mutation, regulation, expression...yeah, we'll cover all of that and more.

6 AP® Biology—Semester A - Evolution

We’ve been through the basics of genetics, but how does that translate into evolution? How do populations change over generations? How do we even know evolution is happening now and has happened in the past? In this unit, we'll lift the veil and demystify what evolution is, how it works, and the piles and piles of evidence scientists have used to learn about it in the past, present, and future.


Recommended prerequisites:

  • Biology—Semester A
  • Biology—Semester B

  • Sample Lesson - Introduction

    Lesson 2.03: Eukaryotes

    An 1855 cartoon about the filthy state of the Thames River.
    "Dude. Get out of my cesspool."
    (Source)

    Back in the good old days, being a prokaryote was fun. A bacterium could relax and let its hair down. They didn't have to share the cesspool, the archaeal cell next door was always excreting the tastiest treats, and the local softball team, the Chemotrophs, were off to a great start. Then one day, some bacterium got a little too big for his breeches and decided to eat that archaeal cell next door. And just like that, blamo! A eukaryote was born.

    Scientists believe that eukaryotes likely evolved when one prokaryote ate another and the one that got eaten just kept doing its thing from inside the other cell. After several billion years of evolution, we now have protists, fungi, algae, plants, and animals all wiggling around on planet Earth.

    Even though we are pretty different from plants and fungi (well, at least we like to think so), our cells have a lot of similarities thanks to that common eukaryotic ancestor. In this lesson, we'll go over the structure and function of organelles found in eukaryotic cells. We'll also do some comparing and contrasting between the prokaryote and eukaryote camps.


    Sample Lesson - Reading

    Reading 2.2.03: The Inside Stuff

    Let's look inside you. Say "Ahhhh." If you have a microscope handy, we can take a swab of your cheek cells and look at them up close and personal. Or you can read about the inner workings of your eukaryotic cells without lifting a finger, or donating part of your cheek, by checking out this reading.

    Pay attention to all of the terms in the reading. There are a lot of cellular components to get familiar with, and in future units, we'll be referring back to these organelles. Take some notes on their form and function, and perhaps even make a few sketches in your notes. Colored pencils and 3D rendering optional.

    Now that introductions are over, let's deep dive into the different organelles eukaryotic cells can have. They're what set the eukaryotes apart from the prokaryotes, after all. This reading has all the deets.

    These cellular mini organs aren't stand-alone units. They interact with each other like dancers in a ballet (or if ballet isn't your thing, like the way trainers interact with their Pokémon). Each organelle has a specific job to do, and once they've completed that job, they send their products to the next organelle to be processed, packaged, or shipped, much like the way the post office handles packages. Luckily for us, our organelles are a lot more efficient than human-involved mail handling.

    Cells with Walls

    Whew. Cells have lots of organelles, but the fun doesn't stop there. There are a few organelles that are unique to plant and fungi cells. Animals are all jealous, so best not to mention their lack of chloroplasts or cell walls if you don't want a passive aggressive episode on your hands.

    They'll get over it, because there are a few cell structures of which animals can be proud. Read about the animal-only organelles here.

    Summary

    • Eukaryotes are cells with organelles, like nuclei and mitochondria. They're more complex than their prokaryote cousins are.
    • Eukaryotes and prokaryotes share a few common features, like cytoplasm and cytoskeletons. Just like in prokaryotes, the cytoskeleton helps give the cell its shapely figure and move components around the cell.
    • Eukaryotic cells are full of organelles, so know which ones go where and what they do. Here's a very brief description (in alphabetical order), but go back to the linked readings or the Terms list for more info.
      • Cell wall: In plants and fungi (and prokaryotes), the cell wall provides added structural stability for the cell and serves as a permeability barrier.
      • Centrioles: Barrel-shaped protein tubes found in animal cells that aid in cell division.
      • Chloroplasts: The photosynthetic organelles found in plants. These guys absorb energy from the sun and use it to start a chain reaction that leads to sugar formation.
      • Cytoplasm: The liquid insides of the cell (called cytosol) plus all the organelles.
      • Endoplasmic reticulum: Comes in rough and smooth varieties. Rough ER makes proteins and smooth ER makes lipids.
      • Golgi body: The shipping department at Cell & Co. The Golgi receives lipids and proteins from the endoplasmic reticulum and processes them and packages them into vesicles for transport or secretion.
      • Lysosomes: These are the garbage men of the cell. They gobble up cellular debris and waste products through phagocytosis and then digest them.
      • Mitochondria: The energy factories of the cells. These little guys are the site of cellular respiration and turn sugar into ATP energy.
      • Nucleus: The brain of the cell. This is where the DNA lives and where it gets transcribed into RNA to direct protein synthesis.
      • Plasmodesmata: Spaces in the cell wall of plants that allows intercellular communication to occur.
      • Ribosomes: The site of protein synthesis in the cell. These are found in all forms of life. The rough ER is bound with lots of ribosomes to facilitate polypeptide production.
      • Vacuole: In plants, the vacuole is the largest structure in the cell and is a water tank that fills with water to maintain turgor pressure. Animals and fungi have vacuoles too, but they're much smaller and are storage compartments for all sorts of chemical necessities.
      • Vesicles: Little membrane bubbles that bud off the Golgi body. These are like shipping containers that take proteins and lipids to their final destination.

    Sample Lesson - Activity

    Activity 2.03a: Organelle Report Cards

    Remember elementary school? Those were the days. We brought home report cards with stickers and good grades for sitting crisscross applesauce (spoon in the middle, optional). Today we're going to draw on the good ole days and send some organelles back to kindergarten.

    Today, let's imagine that we're kindergarten teachers for a subcellular classroom full of organelles. Soon it will be report card time, and it is your responsibility to tell the proud parents how their little organelles are doing within your cell. Everyone knows that kindergarten is where you learn to play well with others. Do these organelles play well with others? With whom do they interact? What are their favorite activities? Can they color inside the lines?

    Pick two organelles, one common to all eukaryotes and one that's unique to only one type of cell (animal, plant, or fungi), and write up report cards for each of them. Go back to the information from this lesson's Reading to help you. If you need to fill in any gaps, the British Society for Cell Biology has some useful information on cells and their organelles (scroll about halfway down the page and there are links for each organelle).

    At a minimum, your report card needs to answer the following questions:

    • What is the organelle's name?
    • How does the organelle spend its time in class (i.e. in the cell)?
    • How does the organelle interact with others in the class?
    • What is the quality of work the organelle produces and how/where are those products used in the cell?
    • How does the organelle contribute to the cell's overall function?
    • What would happen to the cell if the organelle is absent or refuses to participate?

    You should format your report card like an actual report card. There are tons of templates on the interwebs that you can use that will provide inspiration. It's also totally fine to give your student bad grades if you're drunk with power from being teacher for a day. Just make sure you explain why the organelle isn't cutting it and ways it could improve.

    When you're done, you should have two report cards ready to send home to some anxious organelle parents. Since organelles don't have parents, though, just upload them to your teacher using the button below.


    Sample Lesson - Activity

    1. Which organelle is responsible for the synthesis of both lipids and proteins?

    2. In the cell, waste products are generated during normal metabolism of larger molecules. Which organelle is responsible for collecting these waste products and eliminating them from the cell?

    3. Which of the following does not correctly match the organelle with its function?

    4. In plant cells, what is the purpose of the large central vacuole?

    5. What kind of cell is pictured below?