Physical Danger
You may get some carpal tunnel syndrome using Adobe Illustrator or other CAD program, but that's the least of your worries.
Jewelry-making requires a whole lot of chemicals and sharp tools, so be careful. Okay, so you're not going to saw a whole arm off with your tiny torches and lasers, but you can still hurt yourself pretty seriously.
Also, the only thing burglars and con-artists and heist organizers love more than stealing money from banks is stealing precious jewelry. We're not saying you should prepare to be burgled, just know that it's a thing that's a little more common in this line of work.