Quote 16
This last, however, was not so easy of accomplishment; for Mr. Hyde had numbered few familiars—even the master of the servant maid had only seen him twice; his family could nowhere be traced; he had never been photographed; and the few who could describe him differed widely, as common observers will. Only on one point were they agreed; and that was the haunting sense of unexpressed deformity with which the fugitive impressed his beholders. (4.18)
In other words, Mr. Hyde doesn’t have any friends. His isolation is a consequence of his evil nature.
Quote 17
The newsboys, as he went, were crying themselves hoarse along the footways: "Special edition. Shocking murder of an M.P." That was the funeral oration of one friend and client; and he could not help a certain apprehension lest the good name of another should be sucked down in the eddy of the scandal. It was, at least, a ticklish decision that he had to make; and self-reliant as he was by habit, he began to cherish a longing for advice. (5.21)
Mr. Utterson does not want the murder of one friend to cause the ruin of another—yet his conscience does prick him regarding Hyde’s letter.
Quote 18
On the 8th of January Utterson had dined at the doctor's with a small party; Lanyon had been there; and the face of the host had looked from one to the other as in the old days when the trio were inseparable friends. On the 12th, and again on the 14th, the door was shut against the lawyer. "The doctor was confined to the house," Poole said, "and saw no one." On the 15th, he tried again, and was again refused; and having now been used for the last two months to see his friend almost daily, he found this return of solitude to weigh upon his spirits. The fifth night he had in Guest to dine with him; and the sixth he betook himself to Dr. Lanyon's. (6.2)
Mr. Utterson is accustomed to dining with friends, in contrast to the evil and solitary Mr. Hyde.